345 Relief Cream Intensive Regenerating Cream, 50 ml

💗 Dr.Althea 345 Relief Cream – one of the best daily companions for problematic skin

Dr.Althea 345 Relief Cream has become one of the brand’s most well-known and popular products for good reason. It is a lightweight yet complex moisturising cream specifically designed for acne-prone, sensitive, combination skin and skin recovering after acne. Its aim is not to cover the skin with a thick, occlusive layer, but rather to simultaneously soothe, hydrate, support the skin barrier and improve uneven skin texture.

The current formula combines tea tree leaf water, niacinamide, panthenol, centella ingredients, beta-glucan, resveratrol, hyaluronic acids, Ceramide NP and Sodium DNA. The manufacturer positions the cream as a non-comedogenic formula tested suitable for sensitive and acne-prone skin, highlighting balanced hydration: it provides comfort without feeling too heavy or greasy.

✨ What can the 345 Relief Cream do?

• Helps soothe reddened, stressed and more sensitive skin after acne.
• Supports the skin’s moisture barrier and helps reduce tight, dry sensations.
• Helps make rougher, uneven skin surfaces appear smoother and more even.
• Provides light hydration without weighing the skin down like traditional rich barrier creams.
• Supports a more even skin tone and routine against post-acne marks with niacinamide.
• Supports a more comfortable skin feel with panthenol, centella, madecassoside and beta-glucan.
• Helps care for the skin barrier’s lipid layer with Ceramide NP.
• Can be used morning and evening and fits well into routines with stronger actives.

🔢 What does the “345” in the name mean?

The 345 product line is based on Dr.Althea’s 3–4–5 Relief System concept: the brand describes the line’s function with three groups of ingredients targeting post-acne and spot care, four nourishing groups and five soothing groups. The key is not a single trendy active, but addressing multiple needs of problematic skin simultaneously: soothing visible irritation, replenishing hydration, supporting the barrier and caring for skin that appears uneven after acne.

This is also why the 345 Relief Cream works in many routines: it can be used as a standalone light moisturiser, post-acne regenerating care or as a comfort-giving barrier cream alongside stronger actives.

🧬 Key active ingredients – and why they are included

Tea Tree Leaf Water (Melaleuca Alternifolia Leaf Water)

The second ingredient in the formula. Tea tree is well known for caring for problematic, acne-prone skin; in this cream it does not act as an aggressive, drying “acne treatment” but as part of the soothing, balancing concept.

Niacinamide

A multifunctional B3 vitamin derivative that supports the skin barrier, more even skin tone and sebum balance. It is especially useful when acne has cleared but reddish or brownish marks and uneven skin texture remain.

Panthenol

A B5 provitamin with hydrating and soothing properties, particularly suitable for sensitive, irritation-prone skin or skin that dries out more easily when using active ingredients. It helps make the formula more comfortable.

Centella asiatica + madecassoside

Centella and its well-known active component madecassoside support the soothing and regeneration of stressed, redness-prone skin. The 345 Relief Cream contains both Centella Asiatica Leaf Water and Centella Asiatica Extract.

Ceramide NP

Ceramides are important components of the skin’s natural lipid barrier. Ceramide NP helps support the protective layer responsible for retaining moisture and defending against external irritants.

Beta-glucan + hyaluronic acids

Beta-glucan, Sodium Hyaluronate and Hydrolyzed Hyaluronic Acid strengthen the formula’s hydrating side. They help the skin feel softer, plumper and less tight without needing a heavy cream layer.

Sodium DNA

Sodium DNA is part of the formula’s regenerating and conditioning ingredients. The 345 Relief Cream should not be viewed as a standalone “PDRN cream” but as a complementary element in a complex barrier-supporting and regenerating formula.

Resveratrol + green tea water + tocopherol

Antioxidant ingredients that help complement the skin’s daily defence system against environmental oxidative stress.

🎯 Who do we recommend it for?

It is especially suitable for acne-prone, combination, sensitive or skin recovering after acne, and when your skin needs both hydration and soothing but you find rich barrier creams too heavy. The manufacturer communicates the current formula as clinically tested non-comedogenic and suitable for sensitive skin.

It also fits well into routines with retinoids, acids or other stronger actives when the goal is not to increase the number of actives but to support skin comfort and barrier.

🫧 Texture and finish

One of the 345 Relief Cream’s great strengths is its texture. It is a lightweight, fast-spreading cream that hydrates without wanting to remain as a thick protective layer on the skin. This is especially advantageous for combination and acne-prone skin, where overly rich creams can often feel uncomfortable. The finish feels hydrated and smoother, not classically greasy or heavy.

🧴 How to incorporate it into your routine?

Normal use: apply an appropriate amount to the face after cleansing, toner and serum as the last moisturising step in your routine. Follow with sunscreen in the morning.

With stronger actives: Dr.Althea specifically recommends the “sandwich method”. Apply a thin layer of 345 Relief Cream, then the retinoid or active product, then finish with another thin layer of cream. This can help reduce dryness and tightness caused by stronger actives and support the skin barrier.

In post-acne routines: can be used after soothing or tone-evening serums. The brand itself treats the 345 Relief Serum + 345 Relief Cream pair as a complete, lightweight barrier care routine for sensitive, acne-prone skin.

💗 Why do we love it?

Because the 345 Relief Cream does exactly what we expect from a truly good hero moisturiser: it doesn’t try to be spectacular at all costs, it simply works in many different skin situations. It does not try to “fix” problematic skin by drying it out, nor does it equate barrier care with a thick, greasy cream. It combines hydrating, soothing, barrier-supporting and tone-caring ingredients in a light texture.

That’s why it can be a great choice both for younger, acne-prone combination skin and for skin that sometimes becomes sensitive while using active ingredients. This versatility is likely one reason why 345 Relief Cream has become one of Dr.Althea’s most well-known products.

❓ Q&A – common questions about 345 Relief Cream

Can it be used on acne-prone skin?

Yes. The current formula is specifically positioned by the manufacturer for acne-prone skin and is clinically tested as non-comedogenic.

Is it too much for oily or combination skin?

This is actually one of the cream’s strengths: it is designed for balanced hydration with a light finish. If your skin is very oily, start with a small amount; you can apply more to drier areas as needed.

Is it enough on its own for dry skin?

For mildly or moderately dry skin, yes, but for very dry skin with a damaged barrier, you may need a hydrating serum underneath or a richer, lipid-replenishing layer on top.

Can I use it alongside retinol or retinal?

Yes. The manufacturer specifically recommends the sandwich method with stronger actives: thin cream layer, retinoid, then another cream layer.

Can it be used with acids?

Yes, it fits well as a hydrating and barrier-supporting step in acid routines. If your skin becomes irritated, reduce the frequency of actives and simplify your routine.

Is this a PDRN cream because of Sodium DNA?

It contains Sodium DNA, but the main concept of 345 Relief Cream is not PDRN. If you are looking for a regenerating product with a higher PDRN content, Dr.Althea PDRN Reju 5000 Cream is a more targeted choice.

Can it be used morning and evening?

Yes. Use it before sunscreen in the morning and as the last step in your routine in the evening.

How long until results are visible?

A more hydrated, comfortable skin feel can be noticeable in the short term, while a more even tone and improvement in post-acne marks require consistent, longer-term use.